Sometimes I like to fantasize about not eating. At all. For long periods of time, like political statement long. Just let myself whither away. Muscle. Fat. Skin. Hair. Nails. Teeth. Let it all beg for salvation. But just let it all die. I don't think that I'D die this way, rather, I think I see it as a rebirth. A way to shed all the muscle that reminds me how strong I USED to be, and the skin that reminds me how clear it USED to be, and the fat that reminds me just how fat I AM. A way to put a pile of plates in the ground and cover it in dirt. A way to grow daisies with memories, instead of dreams. Are pain and results directly proportional? They just might be. I'm sure that all things worthwhile are painful, but I'm not yet positive that the most worthwhile are also the most painful. Is there any way else that I could be? I don't think so. So for the ultimate birth, I guess I'd be needing the ultimate death.
"Give me love
Give me love
Give me peace on earth
Give me light
Give me life
Keep me free from birth
Give me hope
Help me cope, with this heavy load
Trying to, touch and reach you with,
heart and soul
O(h)m my Lord...
Please take hold of my hand, that
I might understand you
Won't you please
Oh won't you"
Give Me Love by George Harrison
I sometimes wish that I could flit in and out of people's lives unquestioned. That I was able to be there for a moment, make an impact, and then float away secretly lonely. This seems impossible though, as the more that I make myself emotionally available, the more people realize how few people are willing to do this. This realization is followed usually by an immense request. That's okay, that's why I'm here. But how great would it be to be KNOWN for being absent all the time except when you need it most? Would people demand less, but expect more? I'd love that, I think.
"I look at you all see the love there that's sleeping
While my guitar gently weeps
I look at the floor and I see it needs sweeping
Still my guitar gently weeps
I don't know why nobody told you how to unfold your love
I don't know how someone controlled you
They bought and sold you.
I look at the world and I notice it's turning
While my guitar gently weeps
With every mistake we must surely be learning
Still my guitar gently weeps
I don't know how you were diverted
You were perverted too
I don't know how you were inverted
No one alerted you.
I look at you all see the love there that's sleeping
While my guitar gently weeps
Look at you all . . .
Still my guitar gently weeps."
While My Guitar Gently Weeps by George Harrison
I rarely get overwhelmed, but sometimes I feel like giving up. It seems so silly to me that nothing bad happens to ME, but instead to all of the people in my life. Is this an indication that the universe really does revolve around me? I had a decent upbringing, never really wanting much more than I got. I wasn't abused or lied to. I didn't make any major mistakes, and I wasn't the victim of someone else's. I haven't wasted love, and I realize how big that is. So why don't I have cancer? Why aren't I addicted? Why haven't I lost the love of my life? What's the deal? Is this all build up until the major event that will truly destroy me? When it gets to be too much, I like to think that I have a strategy, but it mostly involves trying not to cry, even if I'm sitting alone.
"Once there was a way to get back homeward
Once there was a way to get back home
Sleep pretty darling do not cry
And I will sing a lullaby
Golden slumbers fill your eyes
Smiles awake you when you rise
Sleep pretty darling do not cry
And I will sing a lullaby
Once there was a way to get back homeward
Once there was a way to get back home
Sleep pretty darling do not cry
And I will sing a lullaby"
Golden Slumbers by The Beatles
I really like when sitcoms have dramatic episodes. For instance, I love the episodes of Fresh Prince of Bel-Air when Will's dad shows up and gets back into Will's heart, only to break it again at the end. In all honesty, and at the risk of sounding like a geek, this was the episode that proved Will Smith's acting ability. At the end, he breaks down, and everytime I watch it, I still secretly cry. The only thing that has changed since the first time that I saw it is that if I'm alone I'm not ashamed to cry. The series finale of Roseanne is also excellent. In the last season or so, the show gets really weird. They win the lottery, Roseanne/Jackie's mom comes out as a lesbian, Dan has a heart attack, Jackie starts dating the Prince of Moldavia, Dan cheats on Roseanne, Darlene and David's baby is delivered premature and is supposed to die but lives. So anyways, it sounded really like the show had jumped the shark, but the last episode reveals that the season was a creation of the character of Roseanne, who took up writing as a coping strategy after Dan's heart attack, which he actually died from. The rest of the season is basically her way of running away or fantasizing, which is why so much great stuff happened. What really happened is: Jackie is a lesbian, her mother is not, Dan died from his heart attack, Darlene's baby (with Mark, not David) was delivered premature and somehow survived, Becky had gotten together with David, and Roseanne had begun writing. Anyways, in the series finale, when she exposes all of this, she comes to the point of telling about Dan dying and she almost starts crying, and I almost do as well. There was also an earlier episode I think where Dan's dad dies or something, and Dan cries, and it's pretty hard for me to watch as well. Now that I think about it, there was another episode of Fresh Prince that makes me cry, but I can't remember what it was. There was an episode of Scrubs that did as well, but I can't quite remember it well enough at this point to talk about it. Maybe I'll make a post of the things that have made me cry in my life. I can probably remember just about all of them. Here's a teaser: Fresh Prince, Roseanne, Julee, Paul, Magnolia, Armageddon, About Schmidt, Castaway, and some other stuff as well.
"Words are flowing out like endless rain into a paper cup,
They slither wildly as they slip away across the universe
Pools of sorrow, waves of joy are drifting through my open mind,
Possessing and caressing me.
Jai guru deva, om,
Nothing's gonna change my world,
Nothing's gonna change my world.
Nothing's gonna change my world.
Nothing's gonna change my world.
Images of broken light which dance before me like a million eyes,
They call me on and on across the universe,
Thoughts meander like a restless wind inside a letter box
They tumble blindly as they make their way
Across the universe
Jai guru deva, om,
Nothing's gonna change my world,
Nothing's gonna change my world.
Nothing's gonna change my world.
Nothing's gonna change my world.
Sounds of laughter shades of life are ringing
Through my opened ears inciting and inviting me
Limitless undying Love which shines around me like a
million suns, It calls me on and on
Across the universe
Jai guru deva, om,
Nothing's gonna change my world,
Nothing's gonna change my world.
Nothing's gonna change my world.
Nothing's gonna change my world.
Jai guru deva
Jai guru deva
Jai guru deva
Jai guru deva"
Across the Universe by The Beatles
Wednesday, December 12, 2007
Strange Strange Time
Paper Bag
I was staring at the sky
Just looking for a star
To pray on, or wish on
Or something like that
I was having a sweet fix
Of a daydream of a boy
Whose reality I knew
Was a hopeless to be had
But then the dove of hope began its downward slope
And I believed for a moment that my chances were
Approaching to be grabbed
But as it came down near, so did a weary tear
I thought it was a bird, but it was just a paper bag
Hunger hurts, and I want him so bad, oh it kills
'Cause I know I'm a mess he don't wanna clean up
I got to fold 'cause these hands are too shaky to hold
Hunger hurts, but starving works, when it costs too much to love
And I went crazy again today, looking for a strand to climb
Looking for a little hope
Baby said he couldn't stay put, wouldn't put his lips to mine,
And a fail to kiss is a fail to cope
And I said, "Honey, I don't feel so good, don't feel justified
Come on put a little love here in my void"
He said, "It's all in your head"
And I said, "So's everything'" but he didn't get it
I thought he was a man but he was just a little boy
Hunger hurts, and I want him so bad, oh it kills
'Cause I know I'm a mess he don't wanna clean up
I got to fold 'cause these hands are too shaky to hold
Hunger hurts, but starving works, when it costs too much to love
Hunger hurts, but I want him so bad, oh it kills
'Cause I know I'm a mess he don't wanna clean up
I got to fold because these hands are just too shaky to hold
Hunger hurts, but starving works, when it costs too much to love
Oh hunger hurts, but I want him so bad, oh it kills
Because I know that I'm a mess that he don't wanna clean up
I got to fold because these hands are just too shaky to hold
Hunger hurts, but starving it works, when it costs too much to love
Duffy a no go
Duffy's a non viable option tonight. She has to open tomorrow morning (aka wake up at 4:30), so I told her never mind. We are going to go to lunch though I think. We'll see what happens. Updates to come as necessary. Erin never called me back.
Leave Them, We Gotta Go
So in my efforts to be there for people, I sometimes fail. I do this mental triage thing that basically says, "Okay, so who needs the most right at this moment? Who needs the second most? Ok, go." Should the triage instead be "Who matters the most to you at this moment"? It's hard, I guess. It's hard to look at three people, decide that you only have time for two, and just hope the other one understands. Combine this with my abstract concept of time (you'll notice, if you speak to me on the phone, how rarely I can actually say what day something happened on). I find that a week passes by before I realize even a day is gone. I hope that my friends grasp this about me, and that they will grant me their patience.
I hadn't spoken to Erin for a while (relatively), and I thought that she was mad at me, because every time we DID talk, she said very little:
Me: "So how was your day?"
Erin: "Fine."
Me: "...What did you do?"
Erin: "Work."
Me: "Anything happen at work?"
Erin: "No, just work stuff."
Me: "NOTHING happened today?" (this is the point at which my sensibility demands you to recognize at least ONE positive aspect of the day, so learn to identify this question)
Erin: "NO, just work. What do you want me to say?"
Me: "I don't know, SOMETHING"
Erin: "Ok, fine, I woke up, felt like shit, drove to work, got bitched at by my boss, did everyone's work like I always do, then I left work and now I'm talking to you."
Me: "Sounds like fun"
Erin: "Yeah, it was a blast"
Me: "..."
Erin:
Me: "..."
Erin:
Me: "You alright?"
Erin: "..."
Me: "Hello??? Are you alright?"
Erin: "What? Yeah! I'm fine!"
Me: "..."
Erin: "..."
So then I was supposed to go to this Christmas Party with her, but she told me that day that I wasn't going, and that she wasn't mad at me, and that she felt like shit. I felt bad, because I knew what she was doing (thinking that she was doing me a favor by not making me go, even though I actually did want to go), and I knew that there was no way around it. I intended to call her the next day, but some shit went down with Heather, and frankly, I forgot about it. And now it's Wednesday, and I was going to call her before I did anything with Duffy, but she called me first and was pissed off that I hadn't called her. Then she either hang up on me or her phone died (her phone always dies) after I told her about the week.
I wonder if it's better to spread it out or concentrate. It's not quite the 99 vs 1 conundrum that I thought it was (100 sheep, 1 runs away, shepherd leaves the 99 to find the 1, etc etc). I'm okay with that problem, but I find this is distinctly different. This is more like I have 100 sheep on a mountain rim and 3 of them run away. Two of them run straight at a cliff that's still about a mile away, and the other one starts walking down a path into the dark valley below us. Now, do I stop the one that is easiest to stop and then hope that I still have enough time to catch up to the other two? Or do I take off after the other two knowing that it'll be hard, but ultimately possible, to eventually get the third? The choice seems obvious, but the obvious answer is not always the right one.
"But I can't do this all on my own
No, I know I'm no Superman
I'm no Superman"
Superman by Lazlo Bane
Girl for Tonight
So tonight should be really the first test of my assumption regarding Duffy (the assumption being that she is interested). She is going to call me after a little while, and we are going to do something. I have no idea what, but I'm about to clean my room/part of the house in case we end up just chilling out here. She is JUST getting over being sick, so she might not want to go anywhere that requires her to be outside (we tend to walk around shopping centers and the such), so I should probably be ready for just chillin out here. In fact, I should be cleaning now. I was going to quote Mest (hence the title of this entry), but I hate Mest. So here is one of the more hilarious lyrics ever written:
"Whitney, don't you understand that what I say is true?
I just want you to know I have a major crush on you.
I'd drive you to Las Vegas and do the things you wanna do
I'd even have Wayne Newton dedicate a song to you."
San Dimas High School Football Rules by The Ataris
Born to be a Lawyer
http://www.sullivanandcromwell.com/lawyers/detail.aspx?attorney=140
credits to barzelay.net
Johnny Five ALIVE
Took my last final. Finale ultimo. 50 questions. 8 minutes. I'm the bomb.
Here are my reported grades:
HHS405 - A+
No one else has posted any yet. Damn them.
Poor poor Pat Smear
So in working on this final homework for Bio, I wikipediaed "pap smear" and got this helpful suggestion:
"For the similarly named guitar player and actor see Pat Smear"
change your name already
Cervies pt II
Cochrane Library search terms: antioxidant AND cancer
Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement.
Author(s) Henning SM, Niu Y, Lee NH, Thames GD, Minutti RR, Wang H, Go VL, Heber D
Source The American journal of clinical nutrition
Date of Publication 2004 Dec
Volume 80
Issue 6
Pages 1558-64
Abstract BACKGROUND: Green and black tea polyphenols have been extensively studied as cancer chemopreventive agents. Many in vitro experiments have supported their strong antioxidant activity. Additional in vivo studies are needed to examine the pharmacokinetic relation of absorption and antioxidant activity of tea polyphenols administered in the form of green or black tea or tea extract supplements. OBJECTIVE: The purpose of this study was to compare the pharmacokinetic disposition of tea polyphenols and their effect on the antioxidant capacity in plasma 8 h after a bolus consumption of either green tea, black tea, or a green tea extract supplement. DESIGN: Thirty healthy subjects were randomly assigned to 3 different sequences of green tea, black tea, or a green tea extract supplement in a 3 x 3 crossover design with a 1-wk washout period in between treatments. RESULTS: Flavanol absorption was enhanced when tea polyphenols were administered as a green tea supplement in capsule form and led to a small but significant increase in plasma antioxidant activity compared with when tea polyphenols were consumed as black tea or green tea. All 3 interventions provided similar amounts of (-)-epigallocatechin-3-gallate. CONCLUSIONS: Our observations suggest that green tea extract supplements retain the beneficial effects of green and black tea and may be used in future chemoprevention studies to provide a large dose of tea polyphenols without the side effects of caffeine associated with green and black tea beverages.
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[Enhancement of antioxidant capability of cancer patients during chemotherapy by reduced glutathione]
Author(s) Zhu BD, Li X, Zhao QC, Huang XL
Source Ai zheng = Aizheng = Chinese journal of cancer
Date of Publication 2004 Apr
Volume 23
Issue 4
Pages 452-5
Abstract BACKGROUND & OBJECTIVE: It is unknown how administration of reduced glutathione (GSH) affects chemotherapy of cancer patients. This study was designed to investigate the effect of GSH on lipid peroxidation, and activities of antioxidant enzyme among cancer patients with chemotherapy. METHODS: Sixty-two cancer patients with chemotherapy were enrolled randomly into AB or BA group in cross-over pattern. In AB group, combination of chemotherapy and GSH was administrated first, then following chemotherapy alone was given 21 or 28 days later. In group BA, chemotherapy alone was administrated first, then the combination therapy was given. Duration of chemotherapy was 2-5 days, 21-28 days for a cycle, depended on chemotherapy strategies. GSH was given as a 15 minute intravenous infusion at the dose of 1 500 mgx(m(2)xd)(-1) for 7 days from day 1. Serum samples were collected from the patients on the day just before the chemotherapy, the 7(th) day, and the 21(st) (if 21 days per cycle of the chemotherapy) or 28(th) day of treatment. Concentration of malondialdehyde (MDA), activity of glutathione peroxidase (GSH-Px), and total superoxide dismutase (T-SOD) of serum samples were analyzed biochemically. RESULTS:(1)Administration of chemotherapy significantly increased serum MDA level on the 7(th) day compared with that before chemotherapy (mean+/-SD,6.12+/-1.94 micromol/L versus 4.63+/-1.87 micromol/L,P< 0.01). The increased serum MDA level was restored partially (5.05+/-2.07)micromol/L on the 21(th) or 28(th) day, but still higher than that before chemotherapy (P< 0.05). (2)Serum activity of T-SOD and GSH-Px decreased on the 7(th) day (P< 0.01) and restored partially on the 21(th) or 28th day, but still lower than that before chemotherapy (T-SOD, P< 0.05;GSH-Px,P< 0.01).(3)Co-treatment of GSH prevents lipid peroxidation and depletion of antioxidant enzymes by chemotherapy partially but significantly (P< 0.01). (4)Similar results were obtained in both AB group and BA group. CONCLUSION: Chemotherapy depletes antioxidant capability of cancer patients and co- treatment of GSH might prevent such depletion.
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Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.
Comments Comment in: Br J Nutr. 2004 Feb;91(2):171-3. PMID: 14756900.
Author(s) Wachtel-Galor S, Tomlinson B, Benzie IF
Source The British journal of nutrition
Date of Publication 2004 Feb
Volume 91
Issue 2
Pages 263-9
Abstract Lingzhi (Ganoderma lucidum) is a woody mushroom highly regarded in traditional medicine and is widely consumed in the belief that it promotes health and longevity, lowers the risk of cancer and heart disease and boosts the immune system. However, objective scientific validation of the putative health benefits of Lingzhi in human subjects is lacking, and issues of possible toxicity must be addressed. The present double-blinded, placebo-controlled, cross-over intervention study investigated the effects of 4 weeks Lingzhi supplementation on a range of biomarkers for antioxidant status, CHD risk, DNA damage, immune status, and inflammation, as well as markers of liver and renal toxicity. It was performed as a follow-up to a study that showed that antioxidant power in plasma increased after Lingzhi ingestion, and that 10 d supplementation was associated with a trend towards an improved CHD biomarker profile. In the present study, fasting blood and urine from healthy, consenting adults (n 18; aged 22-52 years) was collected before and after 4 weeks supplementation with a commercially available encapsulated Lingzhi preparation (1.44 g Lingzhi/d; equivalent to 13.2 g fresh mushroom/d) or placebo. No significant change in any of the variables was found, although a slight trend toward lower lipids was again seen, and antioxidant capacity in urine increased. The results showed no evidence of liver, renal or DNA toxicity with Lingzhi intake, and this is reassuring. The present study of the effects in healthy, well-nourished subjects provides useful, new scientific data that will support controlled intervention trials using at-risk subjects in order to assess the therapeutic effect of Lingzhi in the promotion of healthy ageing.
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A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients.
Comments Comment in: J Natl Cancer Inst. 2005 Apr 6;97(7):468-70. PMID: 15812064.
Author(s) Bairati I, Meyer F, Gélinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Têtu B, Harel F, Mâsse B, Vigneault E, Vass S, del Vecchio P, Roy J
Source Journal of the National Cancer Institute
Date of Publication 2005 Apr
Volume 97
Issue 7
Pages 481-8
Abstract BACKGROUND: Although low dietary intakes of antioxidant vitamins and minerals have been associated with higher risks of cancer, results of trials testing antioxidant supplementation for cancer chemoprevention have been equivocal. We assessed whether supplementation with antioxidant vitamins could reduce the incidence of second primary cancers among patients with head and neck cancer. METHODS: We conducted a multicenter, double-blind, placebo-controlled, randomized chemoprevention trial among 540 patients with stage I or II head and neck cancer treated by radiation therapy between October 1, 1994, and June 6, 2000. Supplementation with alpha-tocopherol (400 IU/day) and beta-carotene (30 mg/day) or placebo began on the first day of radiation therapy and continued for 3 years after the end of radiation therapy. In the course of the trial, beta-carotene supplementation was discontinued after 156 patients had enrolled because of ethical concerns. The remaining patients received alpha-tocopherol or placebo only. Survival was evaluated by Kaplan-Meier analysis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS: After a median follow-up of 52 months, second primary cancers and recurrences of the first tumor were diagnosed in 113 and 119 participants, respectively. The effect of supplementation on the incidence of second primary cancers varied over time. Compared with patients receiving placebo, patients receiving alpha-tocopherol supplements had a higher rate of second primary cancers during the supplementation period (HR = 2.88, 95% CI = 1.56 to 5.31) but a lower rate after supplementation was discontinued (HR = 0.41, 95% CI = 0.16 to 1.03). Similarly, the rate of having a recurrence or second primary cancer was higher during (HR = 1.86, 95% CI = 1.27 to 2.72) but lower after (HR = 0.71, 95% CI = 0.33 to 1.53) supplementation with alpha-tocopherol. The proportion of participants free of second primary cancer overall after 8 years of follow-up was similar in both arms. CONCLUSIONS: alpha-Tocopherol supplementation produced unexpected adverse effects on the occurrence of second primary cancers and on cancer-free survival.
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The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.
Comments Erratum in: Arch Intern Med. 2005 Feb 14;165(3):286.
Author(s) Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briançon S
Source Archives of internal medicine
Date of Publication 2004 Nov
Volume 164
Issue 21
Pages 2335-42
Abstract BACKGROUND: It has been suggested that a low dietary intake of antioxidant vitamins and minerals increases the incidence rate of cardiovascular disease and cancer. To date, however, the published results of randomized, placebo-controlled trials of supplements containing antioxidant nutrients have not provided clear evidence of a beneficial effect. We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population. METHODS: The Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) study is a randomized, double-blind, placebo-controlled primary prevention trial. A total of 13 017 French adults (7876 women aged 35-60 years and 5141 men aged 45-60 years) were included. All participants took a single daily capsule of a combination of 120 mg of ascorbic acid, 30 mg of vitamin E, 6 mg of beta carotene, 100 mug of selenium, and 20 mg of zinc, or a placebo. Median follow-up time was 7.5 years. RESULTS: No major differences were detected between the groups in total cancer incidence (267 [4.1%] for the study group vs 295 [4.5%] for the placebo group), ischemic cardiovascular disease incidence (134 [2.1%] vs 137[2.1%]), or all-cause mortality (76 [1.2%] vs 98 [1.5%]). However, a significant interaction between sex and group effects on cancer incidence was found (P = .004). Sex-stratified analysis showed a protective effect of antioxidants in men (relative risk, 0.69 [95% confidence interval [CI], 0.53-0.91]) but not in women (relative risk, 1.04 [95% CI, 0.85-1.29]). A similar trend was observed for all-cause mortality (relative risk, 0.63 [95% CI, 0.42-0.93] in men vs 1.03 [95% CI, 0.64-1.63] in women; P = .11 for interaction). CONCLUSIONS: After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women. Supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene.
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related to above article
Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
Author(s) Galan P, Briançon S, Favier A, Bertrais S, Preziosi P, Faure H, Arnaud J, Arnault N, Czernichow S, Mennen L, Hercberg S
Source The British journal of nutrition
Date of Publication 2005 Jul
Volume 94
Issue 1
Pages 125-32
Abstract The SUpplementation en VItamines et Mineraux AntioXydants (SU.VI.MAX) study, a randomised double-blind, primary-prevention trial showed that after 7.5 years, low-dose antioxidant supplementation lowered the total cancer incidence in men, but not in women. To explain this difference in the impact of antioxidant supplementation in men and women, we hypothesised that the effect of supplementation is dependent on initial antioxidant status; 12 741 French adults (7713 females aged 35--60 years; 5028 males aged 45--60 years) received daily antioxidant supplementation (120 mg vitamin C, 30 mg vitamin E, 6 mg beta-carotene, 100 microg Se, 20 mg Zn daily) or a matching placebo. Cut-off limits for baseline serum concentrations of the different antioxidant vitamins and minerals were defined as follows for both men and women: 0.3 micromol/l for beta-carotene, 11.4 micromol/l for vitamin C, 15 micromol/l for vitamin E, 0.75 micromol/l for Se and 10.7 micromol/l for Zn. The percentage of men with serum concentrations under cut-off limits was higher for vitamins C and E and beta-carotene in those who developed a cancer than in those who did not. The risk of cancer was higher in men with baseline concentrations of serum vitamin C or vitamin E under cut-off limits, but not in women. The effect of supplementation was greater in men with baseline serum concentrations of vitamin C, vitamin E and beta-carotene below the cut-off limits compared with those above it. This effect was maintained only for vitamin E after adjustment for age, tobacco, and alcohol consumption and BMI. No effect of supplementation could be seen in women. Baseline antioxidant status is related to the risk of cancer in men but not in women and therefore does not entirely explain the differences observed in the effect of antioxidant supplementation on cancer risk between sexes in the SU.VI.MAX study.
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Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy.
Author(s) Pongnikorn S, Fongmoon D, Kasinrerk W, Limtrakul PN
Source Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Date of Publication 2003 Jan
Volume 86
Issue 1
Pages 61-8
Abstract Cervical cancer patients have a defective immune system. There is a decrease of total white blood cell count including lymphocytes and natural killer (NK) cells. NK cells, one type of lymphocytes, play a role to eliminate cancer cells by antibody dependent cell mediated cytotoxicity (ADCC) mechanism. Previous studies have shown that P-glycoprotein (170 kDa, transmembrane protein) may be a transporter for cytokine releasing in ADCC mechanism. This study proposed to explore the role of bitter melon intake in cervical cancer patients undergoing normal treatment (radiotherapy). Subjects were divided into three groups: 1) normal control (women 35-55 years, n = 35), 2) patient control (n = 30) and 3) patient treatment (n = 30) groups. Patient control and patient treatment groups were cervical cancer patients (stage II or III) treated with radiotherapy (without or with bitter melon ingestion). Blood samples of patient control and patient treatment groups were analyzed for NK cells percentage and P-glycoprotein level. Bitter melon is a Thai herb. Previous studies have shown that bitter melon can stimulate lymphocyte activity in vitro and in vivo (mouse). The authors hope that bitter melon could stimulate the increase of NK cells percentage and P-glycoprotein level on the membrane in blood samples from cervical cancer patients who ingest bitter melon. The results showed an increased percentage of NK cells in patient control and patient treatment groups. The increase in each group is significant (p < 0.05) when compared with the percentage of NK cells from second and third blood sampling time (after radiation with of without bitter melon intake for 45 and 90 days) with first blood sampling time (before treatment). The results also show a significant decrease of P-glycoprotein level (p < 0.05) in second and third blood sampling times when compared with first blood sampling time of the patient treatment group. There was no significant difference of P-glycoprotein (P-gp) level from first, second and third blood sampling times in patient control group. Bitter melon ingestion did not affect NK cell level but it affected the decrease of P-gp level on NK cell membrane.
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more to come still
"Confront the dark parts of yourself, and work to banish them with illumination and forgiveness. Your willingness to wrestle with your demons will cause your angels to sing. Use the pain as fuel, as a reminder of your strength.”
- August Wilson
