No Shoes Lyrics

No Shoes

(Written by Paranoid Lary, As performed by the Roches)


One, Two Three, Four

I had no shoes
And I complained until I met a man
Who had no feet
That's really beat

I had no feet
And I complained until I met a man
Who had no knees
That was his disease

I had no knees
And I complained until I met a man
And you know what?
He had no butt

I had no butt
And I complained about it all
And then I met a man
Who had no balls

I had no balls
And I complained until I met a man
Who had no guts
No balls, no butt, and now no guts

I had no guts
And I complained until I met a man
Who had no heart
The most important part

I had no heart
And I complained, I did not understand
And then I met a man
Who had no hands

I had no hands
And I complained until I met a man
Who was a wreck
He had no neck

I had no neck
And I complained until I met a man
Who had no chin
Some folks lose, some folks win (Ahhhh)

I had no chin
And I complained until I met a man
Who had no nose
That really blows

I had no nose
And I complained until I met a man
Who never cries
He had no eyes

I had no eyes
And I complained until I met a man
Who felt no pain
He had no brain

I had no brain
And I complained until I met a man
Who had no head
As good as dead

I had no head
And I complained until I met a man
Who had no hair
There was nothing there

I had no hair
And I complained until I met a man
Who had no hat
Picture that. Not even a hat (Ahhhh)

I had no hat (had no hat? no hat!)
And I complained until I met a man
Who had no sky (no sky)
No reason why

I had no sky (why?)
And I complained until I met a man
Who had no stars (he had no stars?)
No Venus or Mars (no Venus or Mars?)

And not any stars!

I had no stars
And I complained until I met a man
Who had no God
That's rather odd

I had no God
And I complained until I met a man
Who had no faith
Nothing just in case

I had no faith
And I complained until I met a man
Who had no love
Nothing to dream of

I had no love
And I complained until I met a man
Who had no hope
At the end of his rope

I had no hope
And I complained until I met a man
Who had no luck
That really sucks

I had no luck
And I complained that I had nothing left to lose
And then I met a man
Who had no shoes... (Ahhhh)

Cervies

National Cancer Institute, US National Institutes of Health "General Information About Cervical Cancer"
http://www.cancer.gov/cancertopics/pdq/treatment/cervical/Patient/page1

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American Cancer Society "What Is Cervical Cancer?"
http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_is_cervical_cancer_8.asp

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A Major Constituent of Green Tea, EGCG, Inhibits the Growth of a Human Cervical Cancer Cell Line, CaSki Cells, through Apoptosis, G1 Arrest, and Regulation of Gene Expression
http://www.liebertonline.com/doi/abs/10.1089/104454903321655846?cookieSet=1&journalCode=dna

(You can buy green tea extract caps that have a shit ton of EGCG in them)

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Surgery for cervical intraepithelial neoplasia

PL Martin-Hirsch, E Paraskevaidis, H Kitchener

Cochrane Database of Systematic Reviews 2007 Issue 4
Copyright © 2007 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
DOI: 10.1002/14651858.CD001318 This version first published online: 26 July 1999 in Issue 3, 1999
Date of Most Recent Substantive Amendment: 19 May 1999

This record should be cited as: Martin-Hirsch PL, Paraskevaidis E, Kitchener H. Surgery for cervical intraepithelial neoplasia. Cochrane Database of Systematic Reviews 1999, Issue 3. Art. No.: CD001318. DOI: 10.1002/14651858.CD001318.

Abstract

Background
Cervical intra-epithelial neoplasia is treated by local ablation or lower morbidity excision techniques. Choice of treatment depends on the severity of the disease.

Objectives
The objective of this review was to assess the effects of alternative surgical treatments for cervical intra-epithelial neoplasia.

Search strategy
We searched the Cochrane Gynaecological Cancer Group trials register and MEDLINE up to July 1997. Update: in July 2004 a further search was conducted.

Selection criteria
Randomised and quasi-randomised trials of alternative surgical treatments in women with cervical intra-epithelial neoplasia.

Data collection and analysis
Trial quality was assessed and two reviewers abstracted data independently.

Main results
Twenty eight trials were included. Seven surgical techniques were tested in various comparisons. No significant difference in eradication of disease was shown, other than between laser ablation and loop excision. This was based on one trial where the quality of randomisation was doubtful. Large loop excision of the transformation zone appeared to provide the most reliable specimens for histology with the least morbidity. Morbidity was lower than with laser conisation, although all five trials did not provide data for every outcome. There were not enough data to assess the effect on morbidity compared with laser ablation.

Authors' conclusions
The evidence suggests that there is no obviously superior surgical technique for treating cervical intra-epithelial neoplasia.

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Cochrane Library search terms "cancer alternative medicine"

Randomized trial of neoadjuvant chemotherapy comparing paclitaxel, ifosfamide, and cisplatin with ifosfamide and cisplatin followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the SNAP01 (Studio Neo-Adjuvante Portio) Italian Collaborative Study.

Author(s) Buda A, Fossati R, Colombo N, Fei F, Floriani I, Gueli Alletti D, Katsaros D, Landoni F, Lissoni A, Malzoni C, Sartori E, Scollo P, Torri V, Zola P, Mangioni C

Source Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Date of Publication 2005 Jun
Volume 23
Issue 18
Pages 4137-45

Abstract PURPOSE: Neoadjuvant chemotherapy may represent an alternative to irradiation in locally advanced squamous cell cervical cancer. Aims of this study were to compare a three-drug (paclitaxel, ifosfamide, and cisplatin [TIP]) with a two-drug (ifosfamide and cisplatin [IP]) regimen and to assess the prognostic value of pathologic response on survival. PATIENTS AND METHODS: Patients (n = 219) were randomly assigned to ifosfamide 5 g/m(2) during 24 hours plus cisplatin 75 mg/m(2), or paclitaxel 175 mg/m(2) plus ifosfamide 5 g/m(2) during 24 hours and cisplatin 75 mg/m(2) every 3 weeks for three courses. RESULTS: Grades 3 to 4 neutropenia, anemia, and thrombocytopenia were more frequent with TIP. We recorded four deaths related to toxicity. The optimal pathologic response (OPT) rate (residual disease < 3 mm stromal invasion) was higher with TIP than with IP (48% v 23%; odds ratio, 3.22; 95% CI, 1.69 to 5.88; P = .0003). At a median follow-up of 43.4 months, 79 women experienced disease progression or died (46 in the IP arm, 33 in the TIP arm). Patients receiving TIP experienced a treatment failure rate 25% less than those receiving IP, but this difference was not statistically significant (hazard ratio [HR], 0.75; 95% CI, 0.48 to 1.17; P = .20). Sixty-one patients died (37 in the IP arm, 24 in the TIP arm), and the HR of death was in favor of TIP, although not significantly (HR, 0.66; 95% CI, 0.39 to 1.10; P = .11). In patients assessable for response (n = 189), the average death rates were higher in the group that did not achieve OPT (HR, 5.88; 95% CI, 2.50 to 13.84; P < .0001). CONCLUSION: The TIP regimen is associated with a higher response rate than the IP regimen, without a statistically significant effect on overall survival. OPT was a prognostic factor for survival.

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Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study.

J Clin Oncol. 2002 Jun 15;20(12):2908-9; author reply 2809-10. PMID: 12065571.
Author(s) Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, Amunni G, Raspagliesi F, Zola P, Mangioni C, Landoni F
Source Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Date of Publication 2002 Jan
Volume 20
Issue 1
Pages 179-88

Abstract PURPOSE: Neoadjuvant chemotherapy (NACT) and radical surgery (RS) have emerged as a possible alternative to conventional radiation therapy (RT) in locally advanced cervical carcinoma. In 1990, a phase III trial was undertaken to verify such a hypothesis in terms of survival and treatment-related morbidity. PATIENTS AND METHODS: Patients with squamous cell, International Federation of Gynecology and Obstetrics stage IB2 to III cervical cancer were eligible for the study. They received cisplatin-based NACT followed by RS (type III to V radical hysterectomy plus systematic pelvic lymphadenectomy) (arm A) or external-beam RT (45 to 50 Gy) followed by brachyradiotherapy (20 to 30 Gy) (arm B). RESULTS: Of 441 patients randomly assigned to NACT+RS or RT, eligibility was confirmed in 210 and 199 patients, respectively. Treatment was administered according to protocol in 76% of arm A patients and 72% of arm B patients. Adjuvant treatment was delivered in 48 operated patients (29%). There was no evidence for any significant excess of severe morbidity in one of the two arms. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 58.9% and 55.4% for arm A and 44.5% and 41.3% for arm B (P =.007 and P =.02), respectively. Subgroup survival analysis shows OS and PFS rates of 64.7% and 59.7% (stage IB2-IIB, NACT+RS), 46.4% and 46.7% (stage IB2-IIB, RT) (P =.005 andP =.02), 41.6% and 41.9% (stage III, NCAT+RS), 36.7% and 36.4% (stage III, RT) (P =.36 and P =.29), respectively. Treatment had a significant impact on OS and PFS. CONCLUSION: Although significant only for the stage IB2 to IIB group, a survival benefit seems to be associated with the NACT+RS compared with conventional RT.

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to continue

"Pain is inevitable. Suffering is optional."
M. Kathleen Casey

Sugar and Spice and Cool As Ice

I was going to buy her a get well card and maybe a flower, but once I got to the Hallmark store, I had to change my strategy. All of their get well cards sucked. So instead, I bought like three of those cards that play music when you open them, and two non musical cards. The music ones included a Buffy the Vampire Slayer birthday, a Grey's Anatomy "hope your life is going alright" card, and a Blazin' Saddles "you have hot tittayz" card. The other two included a fold up that had three pictures of a cat dangling from a branch, and a lame ass get well soon card with some noodle assed chicken. I wrote a tiny note in each one, and a poem in the chicken noodies one. Then I found this cute whale named "Spirtle" that made a sneezing sound, and I wrote "Get WHALE Soon!!!" on its tag thing. I threw all this shiz in a giftbag and left it at her door (she wasn't home at the time). She called me later and we spoke for like an hour or something on the phone about all sorts of crap. If I'm not in by now, then what the frik?

"With all regards,
and regardless of these cards,
I hope you feel better soon."

First Stanza, Healing Poem by Nathies